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Linkage analysis from SGS – linkage analysis to determine the identities of the various linkages between the monosaccharides present

Life Science lab

Throughout all phases of your drug development process, linkage (methylation) analysis of glycoproteins and carbohydrates can be used to determine the identities of the various linkages between the monosaccharides present. Plus, in conjunction with oligosaccharide population analysis, we can provide a detailed picture of the glycans present and identify specific linkages of functional importance, such as 3- versus 6-linked sialic acid.

Why choose linkage analysis from SGS?

Our techniques include Gas Chromatography-Mass Spectrometry (GC-MS) linkage (methylation) analysis to help you:

  • Screen glycoproteins manufactured using different cell lines
  • Demonstrate consistency between batches for release during the manufacturing process
  • Detect potentially immunogenic glycans
  • Meet International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use ICH Q6B requirements for characterization and confirmation of biopharmaceuticals for new marketing applications

Trusted linkage analysis from the leading provider

As the world’s leading provider of linkage analysis, we offer you the experience, technical and regulatory expertise, and unique global network you need.

Contact us today to find out more about our linkage analysis service.